Caspases in apoptosis ppt download

View p53 apoptosis ppts online, safely and virusfree. Ordering of caspases in cells undergoing apoptosis by the intrinsic. Caspases are crucial mediators of programmed cell death apoptosis. Initiator caspases initiate the apoptosis signal while the executioner caspases carry out the mass proteolysis that leads to apoptosis. Cellular pathways and complexes controlling caspase activation.

Programmed cell death and its clinical implications. Apoptosis programmed cell death apoptosis vs necrosis level of stress, change in environment modes of cell death a pathological response to injury chromatin. Apoptosis is a biological mechanism which is one type of programmed cell death. Ppt apoptosis powerpoint presentation free to download. Among them, caspase3 is a frequently activated death protease, catalyzing the specific cleavage of many key cellular proteins. Deathinducing signaling complex and the death receptor pathway. This video will describe the initiator and effector caspases and the role they play during apoptosis. Activation of caspase proteases initiates the death. Caspase role in apoptosis cut off contact with surrounding cells reorganize cytoskeleton shut don dna replication and repair interrupt. Recent studies have suggested that the process of caspase activation differs for initiator caspases, which transduce various signals into protease activity, and.

This proteolytic cascade, in which one caspase can activate other caspases, amplifies the apoptotic signaling pathway and thus leads to rapid cell death. Apoptosis is used by multicellular organisms to remove cells that are not needed by the body. The two pathways both activate initiator caspases, which then activate executioner caspases, which then. The extrinsic apoptosis pathway is activated through the binding of a. Among them, caspase3 is a frequently activated death protease, catalyzing the. A free powerpoint ppt presentation displayed as a flash slide show on id. Activation of caspases during apoptosis results in the cleavage of critical cellular substrates, including polyadpribose polymerase and. Contains an nterminal domain, a small subunit and a large subunit similar to a ribosome. Synthesized in the cell as precursors named procaspase. Mount sinai school of medicine department of pharmacology and biological chemistry cell signaling systems course spring 2005 a free powerpoint ppt presentation displayed as a flash slide show on id. Apoptosis vs necrosis apoptosis chromatin condensation cell shrinkage preservation of organelles and cell membranes rapid engulfment by neighboring cells preventing inflammation necrosis nuclear swelling cell swelling disruption of organelles rupture of cell and release of cellular contents inflammatory. Caspases are essential in cells for apoptosis, or programmed cell death. Emerging roles of caspase3 in apoptosis cell death. Caspases family of proteins main executors of the apoptotic.

This 3d medical animation explains the functioning of the extrinsic and intrinsic apoptotic pathways. Two major apoptotic pathways have been described, the intrinsic pathway involving initial mitochondrial perturbation resulting from cellular stress. Caspase stands for c ysteine asp artate specific prote ase. Caspases caspases or cysteineaspartic proteases or cysteinedependent aspartatedirected proteases are a family of cysteine proteases that play essential roles in apoptosis programmed cell death, necrosis, and inflammation. In my own, presentation on apoptosis is descride in breif over view. The term apoptosis was coined by kerr, wyllie and currie in 1972 to describe a mode of cell death associated with fragmentation of genomic dna kerr et al. Inflammatory caspases do not function in apoptosis but are rather involved in inflammatory cytokine signaling and other types of cell death such as pyroptosis. Both caspase 9 and caspase 8 activate effector caspases.

There are a wide range of caspases which are involved in apoptosis processes. At least 14 different members of caspases in mammalian cells have. Caspases have the characteristics of high specificity for substrates containing asp, and use a cys for catalyzing peptide bond cleavage. Scribd is the worlds largest social reading and publishing site.